4 edition of Nephrotoxicity found in the catalog.
January 1, 1986
Written in English
|The Physical Object|
|Number of Pages||86|
Background: Cisplatin has been used as a chemotherapeutic agent to treat many different cancers. A well-known side effect of cisplatin is nephrotoxicity, which is the primary dose-limiting toxicity. Hydration in conjunction with appropriate diuresis can decrease the incidence of nephrotoxicity. Objectives: This article aims to identify best practices in supportive therapy for patients. Nephrotoxicity is an important and preventable cause of nephrotoxin induced acute kidney injury (AKI) as well as chronic kidney disease (CKD). Drugs and toxins may cause renal injury based on several pathophysiological mechanisms. The spectrum of injury may vary from subtle to severe.
Nephrotoxicity associated with antiretroviral therapy in HIV-infected patients. Curr Drug Saf. May. 2(2) Izzedine H, Launay-Vacher V, Deray G. Antiviral drug-induced nephrotoxicity. Am J Kidney Dis. May. 45(5) Zager RA, Johnson AC, Lund S, Hanson S. Acute renal failure: determinants and characteristics of the. Nephrotoxic definition is - poisonous to the kidney; also: resulting from or marked by poisoning of the kidney. How to use nephrotoxic in a sentence.
Renal Vulnerability to Drug Toxicity Nephrology Self-Assessment Program - Vol 9, No 4, July Clin J Am Soc Nephrol 4: –, Nephrotoxicity and Agents responsible Nephrotoxic injury is damage to one or both kidenys that result from exposure to a toxic substance. Nephrotoxins are chemicals displaying nephrotoxicity. May lead to: More side effects Increased nephrotoxicity Change in the drug metabolism 4. Screening for Acute Kidney Injury 5.
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Nephrotoxicity is a significant treatment complication that has limited the clinical utility of cyclosporine. A number of recent studies have examined novel pathways and potential therapeutic targets in the prevention of cyclosporine nephrotoxicity. This page includes the following topics and synonyms: Nephrotoxic Drug, Nephrotoxin, Drug-induced Nephrotoxicity, Medication Causes of Acute Kidney Injury, Medication Causes of Acute Tubular Necrosis, Medication Causes of Interstitial Nephritis, Medication Causes of Glomerulonephritis, Medication Causes of Prerenal Failure, Medication Causes of Postrenal Failure, Toxic Nephropathy, Drug.
With the advent of effective cytotoxic chemotherapy, attention has turned to the side effects of these widely used agents (Table ). These side effects include tumor lysis syndrome, paraneoplastic glomerulonephritis, obstructive uropathy, and nephrotoxicity with renal failure and electrolyte disturbances.
These are more common in the geriatric population secondary to polypharmacy/drug Author: Christopher J. Logothetis, Vasily Assikis, Jose E. Sarriera. nephrogenic diabetes insipidus and Nephrotoxicity book in animal models Department of Pharmaceutical Sciences JJTU Page 8 Chapter-1 INTRODUCTION Nephrotoxicity: The kidneys are paired and bean shaped organs, located on either sides of the vertebral column.
The File Size: KB. nephrotoxicity: (nef'rō-tok-sis'i-tē), The quality or state of being toxic to kidney cells. Nephrotoxicity is the principal adverse event associated with systemic administration of cidofovir. 94,95 Cidofovir concentrates in renal cells in amounts times greater than in other tissues, producing severe nephrotoxicity involving the proximal convoluted tubule when concomitant hydration and administration of probenecid are not employed.
Patients at highest risk of drug-induced nephrotoxicity are those with one or more of the following: age older than 60 years, baseline renal insufficiency (e.g., GFR Cited by: Nephrotoxicity book Nephrotoxicity can be defined as the adverse effect of substances on renal function (Perazella, ).These substances can include molds and fungi, cancer therapeutics such as cisplatin, antibiotics such as aminoglycosides, metals such as mercury, arsenic and lead, and drugs of Cited by: Define nephrotoxicity.
nephrotoxicity synonyms, nephrotoxicity pronunciation, nephrotoxicity translation, English dictionary definition of nephrotoxicity.
n med the quality of being nephrotoxic. Nephrotoxicity - definition of nephrotoxicity by The Free Dictionary.    The number of patients developing nephrotoxicity increases with duration of therapy reaching 50% if the therapy is continued for 14 days or more.
22 Renal damage caused by. There has been a growing awareness that nephrotoxicity represents a key factor in human nephropathies, where, irrespective of the causative agent, only a few clinical end-effects are diagnosed. Thus nephropathies are generally classified as acute or chronic renal failure, malignancies or.
Aminoglycoside (AG) nephrotoxicity is a well-known occurrence. However, 50 years after the discovery of the first AG (streptomycin), nephrotoxicity is still very difficult to predict and avoid ().To date, no model has completely described the pharmacodynamic behavior of AG nephrotoxicity, even though the mechanism of this toxicity has been widely studied (4, 7, 15, 27).
Drug-induced nephrotoxicity is a renal dysfunction that occurs as a result of exposure to nephrotoxic drugs. It is a common problem in certain clinical situations such as underlying renal dysfunction, cardiovascular disease, diabetes, and sepsis.
Drugs can cause mild to moderate nephrotoxic problems such as intrarenal obstruction, interstitial nephritis, nephrotic syndrome, acid-base and fluid Cited by: 1. The kidneys normally receive 20% of the cardiac output.
Drugs are filtered and/or secreted and then progressively concentrated in the urine. Therefore, these organs are especially vulnerable to the toxic effects of many drugs, including chemotherapy toxicity is often a dose-limiting adverse effect of chemotherapy.
Chemotherapy agents can affect the microvasculature, the glomerulus. Find many great new & used options and get the best deals for Nephrotoxicity: In Vitro and in Vivo, Animals to Man (, Hardcover) at the best online prices at eBay.
Free shipping for many products. Although uncommon, the widespread use of NSAIDs means that renal complications are likely to be seen frequently Two isoforms of COX (COX-1 and COX-2) have been identified in mammalian cells. COX-1, which is constitutively expressed, mediates gastric cytoprotection and vascular homeostasis.
COX-2 expression is regulated by salt and water intake, medullary tonicity, growth factors. Nephrotoxicity: Assessment and Pathogenesis by F. Bonner and a great selection of related books, art and collectibles This is an ex-library book and may have the usual library/used-book markings book has hardback covers.
In fair condition, suitable as a study copy. No dust jacket. Please note the Image in this listing is a. Nephrotoxicity is one of the most common kidney problems and occurs when your body is exposed to a drug or toxin that causes damage to your kidneys.
When kidney damage occurs, you are unable to rid your body of excess urine, and wastes. Your blood electrolytes (such as potassium, and magnesium) will all become elevated. Prospective cohort studies of AKI have documented the frequency of drug-induced nephrotoxicity to be approximately % in adult populations [1–3].
Nephrotoxicity is a significant concern in pediatrics with 16% of hospitalized AKI events being attributable primarily to a drug. The epidemiology of tubular disorders is unclear as a standard Cited by: Nephrotoxicity mechanism 1. Nephrotoxic Mechanisms of Drugs and Environmental Toxins 2.
Nephrotoxic Mechanisms of Drugs and Environmental Toxins Edited by GEORGE A. PORTER, M.D. University of Oregon Health Science Center Portland. Nephrotoxicity may be assessed by a number of different parameters: Urine characteristics Blood levels.
Since the kidneys are _____ there does exist some _____ for dealing with toxic injury. bilateral, compensatory mechanism.Cisplatin nephrotoxicity.
A review Article Literature Review (PDF Available) in Cancer Chemotherapy and Pharmacology 25(1) February with 4, Reads.Nephrotoxicity definition ata free online dictionary with pronunciation, synonyms and translation.
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